Guy Ritchie	...	(Director)
Michele Mulroney, Kieran Mulroney	...	(Writer)
Robert Downey Jr.	...	Sherlock Holmes
Jude Law	...	Dr. John Watson
Noomi Rapace	...	Madam Simza Heron
Rachel McAdams	...	Irene Adler
Jared Harris	...	Professor James Moriarty
Stephen Fry	...	Mycroft Holmes
Paul Anderson	...	Colonel Sebastian Moran
Kelly Reilly	...	Mary Watson
Geraldine James	...	Mrs. Hudson
Eddie Marsan	...	Inspector Lestrade
William Houston	...	Constable Clark
Wolf Kahler	...	Doctor Hoffmanstahl
Iain Mitchell	...	Auctioneer
Jack Laskey	...	Carruthers
Patricia Slater	...	Shush Club Maitre D'

Summary: With Dr. John Watson about to marry and end their partnership, a disconsolate Sherlock Holmes occupies his time investigating the schemes of his archenemy, Professor James Moriarty. However, when Moriarty warns that he considers the Watsons a legitimate target for his retaliation against the detective, Holmes must save them and get John involved in one last case. To do so, they join the Roma lady Madam Simza Heron's quest to find her missing brother, Renee, who may be the key to defeating Moriarty. Together, the trio find themselves involved in a dangerous international conspiracy led by the Napoleon of Crime in which the fate of all of Europe hangs in the balance.